Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0043320010240060527
Archives of Pharmacal Research
2001 Volume.24 No. 6 p.527 ~ p.531
A Cytotoxic Secocycloartenoid from Abies koreana
Kim HJ
Le QK/Lee MH/Kim TS/Lee HK/Kim YH/Bae KH/Lee IS
Abstract
Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9 ¥â- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, togethe r with ¥â- sitosterol (2), maltol (3), ¥â-sitosterol-0-¥â-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.
KEYWORD
FullTexts / Linksout information
Listed journal information
SCI(E) MEDLINE ÇмúÁøÈïÀç´Ü(KCI)